We present twelve years of monitoring of the gravitational lens Q0142-100 from the Teide Observatory. The data, taken from 1999 to 2010, comprise 105 observing nights with the IAC80 telescope. The application of the delta2-method to the dataset leads to a value of the time delay between both components of the system of 72+/-22 days (68 per cent confidence level), consistent within the uncertainties with the latest previous results. With this value in mind a possible microlensing event is detected in Q0142-100.