We report the detection of a hot Jupiter M_p=1.75-0.17+0.14 M_J, R_p=1.38+-0.04 R_J orbiting a middle-aged star (log g=4.152+0.030-0.043) in the Transiting Exoplanet Survey Satellite (TESS) southern continuous viewing zone (beta=-79.59º. We confirm the planetary nature of the candidate TOI-150.01 using radial velocity observations from the APOGEE-2 South spectrograph and the Carnegie Planet Finder Spectrograph, ground-based photometric observations from the robotic Three-hundred MilliMeter Telescope at Las Campanas Observatory, and Gaia distance estimates. Large-scale spectroscopic surveys, such as APOGEE/APOGEE-2, now have sufficient radial velocity precision to directly confirm the signature of giant exoplanets, making such data sets valuable tools in the TESS era. Continual monitoring of TOI-150 by TESS can reveal additional planets and subsequent observations can provide insights into planetary system architectures involving a hot Jupiter around a star about halfway through its main-sequence life.